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Abiraterone Acetate – Overview 💊

Chemical Name: Abiraterone Acetate
CAS Number: 154229-18-2
Molecular Formula: C₂₆H₃₃NO₂

Description:
Abiraterone Acetate is an oral anti-androgen drug primarily used for the treatment of metastatic castration-resistant prostate cancer (mCRPC). It works by inhibiting CYP17 enzyme, which is crucial in androgen biosynthesis. By blocking androgen production in the testes, adrenal glands, and prostate tumor tissue, Abiraterone slows cancer growth and reduces tumor progression.

Appearance:

White to off-white crystalline powder

Odorless

Solubility:

Practically insoluble in water

Soluble in organic solvents such as ethanol

Pharmacological Use:

Treatment of advanced prostate cancer

Used in combination with prednisone to minimize side effects from increased mineralocorticoid levels

Mechanism of Action:

Abiraterone selectively inhibits CYP17 (17α-hydroxylase/17,20-lyase)

Reduces androgen production, depriving prostate cancer cells of growth signals

Dosage Forms:

Oral tablets (commonly 250 mg or 500 mg)

Side Effects (common):

Fatigue, joint swelling, hot flashes

Hypertension, fluid retention, hypokalemia

Rare: liver toxicity